Improved bactericidal properties of ofloxacin loaded on bioadhesive hydrogels against fluoroquinolone resistant Pseudomonas aeruginosa (proceeding)

ROMERO, VL; ROSSET, CI; MANZO, RH; ALOVERO, FL

SPRINGER

Año: 2011 p. 1 - 1

acterial resistance to fluoroquinolones is a major challenge for researchers who seek to preserve the usefulness of these valuable antibiotics used to treat a large variety of infections. In particular, P.aeruginosa infections are difficult to overcome owing to the high intrinsic resistance to antibiotics. Development of new strategies for drug delivery using the concept of mucoadhesion shown to prolong the residence time of dosage forms in the mucosa, allowing sustained drug release remained at a particular target site. That condition allows an intimate contact with the membrane absorption, providing the basis for a high concentration gradient as a driving force for passive drug absorption. Carbomers are synthetic polymer of acrylic acid cross-linked with allylsucrose well established as a good bioadhesive and extensively investigated in the pharmaceutical field. Three carbomers were selected in this work to prepare colloidal aqueous dispersions (hydrogels) with differ